A novel transdermal patch of Metformin was prepared for the sustained release of drug. The transdermal patch of metformin was prepared by solvent casting technique. Bioavailability of metformin is 50-60% and half life is 6.2 hr. HPMC-E50LV, HPMC-E100M and ethyl cellulose was used for matrixing agent and PEG-400 is used as plasticizer. DMSO (dimethyl sulphoxide) is used as penetration enhancer. Methanol and Dichloromethane is use as solvent. Patch are evaluated by thickness, tensile strength, folding endurance, drug content uniformity The data of in-vitro dissolution , % moisture content, % moisture loss, and in vitro release. This patch is use for the treatment of type-II diabetes (diabetes mellitus) it decreases the LDL level and used for over fat persons. The aim of this article for sustained release of drug and main advantages are avoid first pass hepatic metabolism, avoid the risk of intravenous therapy, and increase bioavailability.
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